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KMID : 0356719960120020239
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Journal of the Korean Society of Coloproctology
1996 Volume.12 No. 2 p.239 ~ p.246
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Expression of Cretin Genes in Colorectal Carcinomas
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Baek Won-Ki
Moon Sung-Hee
Suh Seong-Il
Park Jong-Wook
Bae Ok-Suk
Choi Byung-Gil
Suh Min-Ho
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Abstract
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A fundamental cause of cancer is changed properties of genetic material, which may deregulate normal development of the tissue or Provide selective growth advantage to the tumor cell. This deregulation of cell proliferation results from altered production of a handful of proteins that play key roles in progression through the eucaryotic cell cycle. Cyclins are prime cell cycle regulators and are central to the control of major check points in eucaryotic cells. Cyclins were first identified in marine invertebrates on the basis of their dramatic cell cycle periodicity during meiotic and early mitotic divisions.
More than 30 cyclins sequences are now available for comparison. Cyclins function by forming a complex with and activating a family of cyclin-dependent protein kineses(COKs), at various stages in the cell cycle. They fall into three categories: A-type, B-type, and G1 cyclins(cycling C, Dl-D3, and E). In this study, the abundance of cyclins(A, B, C, Dl, E) mRNA expression in normalcolon(n=6), primary(n=6) and metastatic(n=1) colorectal carcinomas, and 3 colon cancer
cell lines were investigated by RT-PCR method. Expression of examined cyclin genes(A,B, C, Dl and E) were increased in all cancer tissues and cell lines. Gene expression of cyclic Dl in 1 cancer tissue and its metastatic cancer tissue, and cyclin I in cell lines(C2A, HT-29) were remarkably increased.
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KEYWORD
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Colorectal Neoplasms, Cyclin
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